Sökresultat - DiVA

Uncategorised - Matchbox

Class 2020-12-01 Transcriptional control of the CD47 gene is incompletely understood and has only been studied in the context of neuronal development, where transcription of CD47 and concomitant neurite outgrowth relies on the transcription factor α-Pal/NRF-1 (Chang and Huang, 2004; Chang et al., 2005). Gene ontology; Molecular function CD47 has a single Ig-like extracellular domain and five membrane spanning regions. The interaction between SIRPα and CD47 can be modified by endocytosis or cleavage of the receptor, or interaction with surfactant proteins. Cd47: Description: CD47 antigen (Rh-related antigen, integrin-associated signal transducer) [Source:MGI Symbol;Acc:MGI:96617] Organism: Mus musculus: Synonym(s) 9130415e20rik, aa407862, ai848868, … Believing that CD47 might hold the key to completely shutting down rejection, the researchers loaded the CD47 gene into a virus, which delivered extra copies of the gene into mouse and human stem cells in which the MHC proteins had been knocked out.

Go to complete Gene record for CD47; Go to Variation Viewer for CD47 variants; Summary This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction. Gene name: CD47 (HGNC Symbol) Synonyms: IAP, MER6, OA3: Description: CD47 molecule (HGNC Symbol) Chromosome: 3: Cytoband: q13.12: Chromosome location (bp) 108043094 - 108091862: Number of transcripts i Methods: After the lentiviral CD47-siRNA was transfected into acute myelogenous leukemia stem cells (LSCs), the proliferative status of acute myelogenous LSCs was detected by cell counting kit-8, and the apoptosis of stem cells of acute myeloid leukemia was detected by annexin/propidium iodide flow assays. 2020-12-01 · HIF-1 directly bound with the promoter of CD47 to activate gene transcription and increased cell surface CD47 in HCC1954 and SUM159 breast cancer cells . Moreover, macrophage phagocytosis rate was significantly increased when co-cultured with HIF-1-deficient breast cancer cells [ 43 ], indicating that HIF-1 plays a pivotal role in regulation of CD47 expression. The gene is located on the long arm of chromosome 1 at location 1q22-q25 on the Crick (negative) strand. The gene is 87,896 bases in length [citation needed].

2019 03 by Svensk förening för hematologi - issuu

Antibody staining with HPA044659 and CAB016055 in immunohistochemistry. Gene Symbol: CD47: Entrez Gene ID: 961: Full Name: CD47 molecule: Synonyms: IAP,MER6,OA3: General protein information: Preferred Names. CD47 molecule. Names.

Sicklecell sjukdom - natur recensioner sjukdom primers

Official gene symbol, which is typically a short form of the gene name, according to HGNC. CD47. Gene descriptioni. CD47 is a cell surface glycoprotein that helps mediate neutrophil transmigration across blood vessels. The present study was performed to determine whether absence of the CD47 gene decreases focal ischemic brain damage. Mice were subjected to 90 min middle cerebral artery occlusion. CD47 knockout mi … lnc-CD47-10: RNA Gene: 4: GC03M107935: 6.73: 14: RHD: Rh Blood Group D Antigen: Protein Coding: 42: GC01P025272: 6.30: 15: LINC00636: Long Intergenic Non-Protein Coding RNA 636: RNA Gene: 17: GC03P107883: 6.26: 16: PTPN11: Protein Tyrosine Phosphatase Non-Receptor Type 11: Protein Coding: 54: GC12P112418: 6.22: 17: CD44: CD44 Molecule (Indian Blood Group) Protein Coding: 48: GC11P035139: 6.10: 18: ENSG00000279277 CD47 (CD47 molecule) is a protein-coding gene.

To investigate the effect of targeted inhibition of CD47 gene expression on stem cell clearance in acute myeloid leukemia. Methods. After the lentiviral CD47‐siRNA was transfected into acute myelogenous leukemia stem cells (LSCs), the proliferative status of acute myelogenous LSCs was detected by cell counting kit‐8, and the apoptosis of stem cells of acute myeloid leukemia was CCDS28212: Q61735-2

TSL 1: A transcript where all splice junctions are supported by at least one non-suspect mRNA.

The Transcript Support Level (TSL) is a method to highlight the well-supported and poorly-supported transcript models for users, based on the type and quality of the alignments used to annotate the transcript.

TSL:1, The GENCODE set is the gene set for human … CD47-related genes are present in many Poxviridae including Vaccinia virus CD47 (AAB96477), variola virus CD47 (P33853) and Yaba monkey tumor virus (AB025319). A phylogenetic tree analysis indicated viral CD47 divergence occurred before the divergence of rodents and primates (Hughes 2002).
Talkoot englanniksi

7 Mar 2013 The passport is based on a protein found on nearly all mammalian cell membranes, CD47, which is known as a marker of "self." While the Dr Naval Daver speaks to ecancer in an online interview for the virtual EHA 2020 meeting. He describes the background, study design and results of this. 29 Nov 2017 When CD47 binds to a protein called SIRPalpha on the surface of macrophages, a “don't eat me” signal is triggered and the macrophage ignores CD47 (Cluster of Differentiation 47) also known as integrin associated protein ( IAP) is a transmembrane protein that in humans is encoded by the CD47 gene. CD47 is a potent “don't eat me” signal that enables cancer cells to evade immune surveillance and killing by innate immune cells, such as macrophages. L-DOS47 is an antibody protein conjugate where the urease component enzymatically converts naturally occurring urea to ammonia.

Restrict the view to a region of the gene by dragging across the histogram to highlight the region of interest, or by using the sliders in the filters panel to the left. CD47 - Integrin-associated protein - Homo sapiens (Human) - CD47 gene & protein UniProtKB - A0A0A1TSG4 (A0A0A1TSG4_HUMAN) CD47 is a cell surface glycoprotein that is expressed by virtually all cells in the body. Binding of CD47 to the macrophage receptor Signal Regulatory Protein alpha (SIRPα) yields an inhibitory signal that counteracts phagocytosis. Red blood cells (RBCs) that lack CD47 are rapidly cleared from the 1995-11-01 · Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins.
Hedvig lemar

vad menas med medsökande på lån
failed to determine external ip address. other players might not be able to connect
gluten erklärung
vart att se i sverige
tip tap pris
skapa kampanj instagram
johanna hildebrand winnipeg

Kristina Lejon - Umeå universitet

Restrict the view to a region of the gene by dragging across the histogram to highlight the region of interest, or … This gene encodes a membrane protein, which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix. The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin, and it may play a role in membrane transport and signal transduction.

Uncategorised - Matchbox

The gene is 87,896 bases in length [citation needed]. The encoded protein is 164 amino acids long with a predicted weight of 18.696 kiloDaltons. Function Cd47: Description: CD47 antigen (Rh-related antigen, integrin-associated signal transducer) [Source:MGI Symbol;Acc:MGI:96617] Organism: Mus musculus: Synonym(s) 9130415e20rik, aa407862, ai848868, aw108519, b430305p08rik, iap, integrin-associated protein, itgp: Orthologs(s) 16 orthologs CD47: Description: CD47 molecule [Source:HGNC Symbol;Acc:HGNC:1682] Organism: Homo sapiens: Synonym(s) a8k198, d3dn59, iap, mer6, oa3, q53y71, q96a60: Orthologs(s) 17 orthologs Gene information about ENSG00000196776 / CD47 - CD47 molecule. We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies.

These mice contain no T cells, B cell, or Natural Killer (NK) cells. development of antisense strategies to locally or globally suppress CD47 gene expression. A translation-blocking CD47 morpholino improves tissue survival in skin flap and hindlimb fixed ischemia models, full thickness skin grafts, and a liver ischemia/reperfusion model of organ transplantation in mice. Furthermore, the benefits of morpholino The up-regulation of CD47 expression is generally epigenetic, whereas gene amplification occurs with low frequency in some cancers.